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The Bottom Line on Fundamental Aging
• Nearly all researchers into the biology of aging agree that the decay of mitochondrial function is a major engine of the aging process.
• Caloric restriction, with adequate nutrition, is the only proven way to slow down the fundamental aging process in mammals.
• Lipoic acid has a reputation as an "anti-aging" supplement.
• The "lipoic acid" in common supplements is a 50/50 mixture of two different "lipoic acid" molecules: the natural R(+)-lipoic acid, and the unnatural S(-)-form. This mixture is called the "racemate."
• Many of the benefits of R(+)-lipoic acid closely mimic those of caloric restriction.
• R(+)-lipoic acid's effects on mitochondrial function are its most striking and unique in parallel with caloric restriction.
• A study in a short-lived strain of mouse demonstrated that R(+)-lipoic acid can dramatically increase its lifespan. Neither S(-)-lipoic acid, nor the racemate, had this power.
• The National Institutes on Aging are currently funding studies to see if lipoic acid can truly slow down the aging process itself.
• Common "lipoic acid" supplements are thus like a house at war with itself. The S(-)-form should be removed from supplements in favor of pure R(+)-lipoic acid.
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