New Study Sheds Light on Best Resveratrol Dosage for Humans

by Dan-N on August 10, 2010

resveratrol-structureWow we are publishing a lot of articles on Resveratrol!  It is not intentional, there have just been a slew of published studies on resveratrol released this summer.

The latest study, published in the Journal of Clinical Endocrinology & Metabolism (yes it really is as exciting as the name makes it sound), shows that a relatively low dosage of resveratrol in humans can have significant health benefits.

Best Resveratrol Dosage Much Less Than Previously Reported

Husam Ghanim, PhD, of the University of Buffalo found that a dosage of 40 milligrams of resveratrol, taken once a day for six weeks, was able to reduce inflammation in test subjects.   Inflammation in humans can lead to heart disease, stroke, and type 2 diabetes – so anything that reduces inflammation is of great interest.

In the study, Dr. Chanim took twenty volunteers and broke them into two even groups of ten.  One group received a placebo pill for 6 weeks.  The second group received a Polygonum cuspidatum extract (Japanese Knotweed) pill that contained 40 milligrams of resveratrol.

Fasting blood samples were taken throughout the study and here are the results…

“Results showed that resveratrol suppressed the generation of “free radicals” — unstable molecules known to cause oxidative stress and release pro-inflammatory substances into the blood, resulting in damage to the blood vessel lining.

People taking resveratrol also showed suppression of the inflammatory protein tumor necrosis factor, or TNF, and other compounds that increase blood vessel inflammation and interfere with insulin action, causing insulin resistance and the risk of developing diabetes.”

- WebMD, Resveratrol May Slow Aging in Humans, By Bill Hendrick

As for the placebo group – they showed no change in blood levels.

Why This Resveratrol Study is Significant

There are three elements that we believe make this study significant.  First, the study was done with humans.  Human studies are always more significant that mouse studies (sorry to any mice readers we have).  Second, the study used only 40 milligrams of Resveratrol.  This shows that resveratrol can be effective in a relatively small dosage. Third, the study used a Japanese Knotweed extract and this therefore lends credibility to resveratrol supplements currently on the market that are made with Japanese Knotweed.

So, is 40mg the Best Resveratrol Dosage for Humans?

Not sure.  First, a much larger study would need to be done to draw really significant conclusions on the best resveratrol dosage for humans.  Second, it is possible that something else in the extract was helping along with the resveratrol.  Third, it would be interesting to see if 100mg  or 200mg produces even better results.

In the end, this study does not prove that any one dosage of resveratrol is best – but it does put to rest the claim that you need to be taking mega-doses of resveratrol (400mg and up) to see any health benefits.  In addition, the best way to avoid resveratrol side effects is to take the minimum amount required to produce positive results.

Resveratrol Update – 10/8/10

As you know we try to keep things non-commercial here on the blog, but our friends at Perfect Supplements sent us samples of their Perfect ResGrape (200mg 99% Trans-Resveratrol per serving) and it is amazing.  We said if we mention this to our readers, we need to give them an incredible coupon!  They came through – 15% off the Perfect ResGrape! Just Click Here to Learn More and Order and enter COUPON CODE: SECRET15 at checkout for the exclusive savings!

Additional Resources:

“An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol.” J Clin Endocrinol Metab. 2010 Jun 9.

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{ 1 comment… read it below or add one }

james February 3, 2011 at 8:14 am

Well, to my mind there is no proven adequate and suffecient dosage for resveratrol. All the studies are done on mice and rats and I find it inproper to calculate the dosage we give on a mouse and use it on human. Further investigations are needed. Pehaps red wine has adequate resveratrol, however we should avoid excessive amounts. I don\\\’t know if 40 mg are adequate, because some studies imply that high doses help. It is better to search pure medical articles on \\\’\\\’pubmed\\\’\\\’ or \\\’\\\’cochrane\\\’\\\’ and the best thing is to read meta-analysis that estimate and assess many studies.

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