Clinically Proven antioxidant that builds muscles and reduces signs of aging...
Alpha lipoic acid (ALA) is a very effective antioxidant that has been shown in numerous clinical studies to
have profound health benefits. On this page we will introduce you to ALA and more specifically the R+ ALA form of
lipoic acid. After this brief introduction we strongly recommend you read our
20 page e-book which details the clinical
research on r-alpha lipoic acid.
What is ALA?
ALA or alpha lipoic acid is a powerful antioxidant that is both fat and water soluble. Since ALA is fat and water soluble it is often
called a ďuniversal antioxidantĒ. Antioxidants are necessary to counter the effects of free radicals on our body. Free radicals are unstable
molecules that can form in our body from pollution, diet, sun exposure and breathing! Yes, oxygen intake, necessary for living, also has the
down side of "rusting" our body. Years of oxidation leads to free radicals, and these free radicals can destroy vital cells in our body. Antioxidants
like ALA work to counteract the free radicals in our body.
How can ALA help me build muscle?
ALA has a unique ability to mimic insulin, this in turn leads to increased uptake of glycogen by your muscles. If you workout, you can begin to
see the benefits of a supplement that increases muscle cell volume and contributes to that full pumped feeling when you workout.
The fact that alpha lipoic acid gives you an incredible pump, is really just a side benefit to us. If you remember from our article
on creatine, getting creatine into the muscles is the key to success. The fact that ALA mimics insulin and increases
muscle glycogen, also means that creatine and other nutrients will be pulled into the muscles when you use ALA. You know that we like
creatine serums because of their ability to be quickly absorbed, well add ALA to the mix and you have an intense combination (our favorite is
DiMaxx Muscle Creatine Plus and R-ALA.)
What else can ALA do for me?
Muscle building is just the tip of the iceberg when it comes to the benefits of ALA. Thousands of studies have been conducted on
Alpha Lipoic Acid, and the results have been impressive. At the bottom of this page we have references to
all the studies.
How could ALA possibly help with all the above conditions?
Alpha lipoic acids has some interesting qualities that help explain its powers. First, ALA is fat and water soluble, so it can enter
any type of cell and destroy free radicals. Second, ALA is one of the very few substances that can actually cross the
blood/brain barrier to enter the brain and protect the cells directly where they need it the most. Third, ALA increases the brain's
level of glutathione. Glutathione is key for strong mental function and low glutathione levels have been
linked to stroke, dementia, Parkinsonís and Alzheimerís disease.
This represents just a brief overview of what makes ALA so powerful, in the online e-book on ALA we will provide much more
detail on how ALA can help people.
ALA sounds great, should I just go to the drug store and get an
alpha lipoic acid supplement?
No! Here is the major catch, that most supplement companies do not want you to know - there are two forms
of ALA - R-ALA and S-ALA.
R-ALA is the form found naturally occurring within the body and is the biologically active
form of alpha lipoic acid.
S-ALA is the unnatural, synthetic byproduct created during the production of alpha
Nobody sells S-ALA by itself as it isnít very effective, but you will get S-ALA anytime you
purchase ALA. The ALA you buy from nutrition stores is in reality a 50/50 mixture of S-ALA & R-ALA
(though they wonít tell you thatÖ). Most companies donít go through the complicated and expensive
process required to purify and remove the synthetic S-ALA from their products. Be aware that unless
the bottle specifically states 100% R-ALA, you are only getting a 50/50 blend.
It is important for you to know that R-ALA has been shown time and time again
to be up to 12 times as effective as S-ALA. There have been many studies, doctors and
researchers who have stated how much more effective R-ALA is.
The benefits of R-Lipoic acid
∑ R-Lipoic acid is the only form of lipoic acid that your body synthesizes and can safely metabolize. (7)
∑ R-Lipoic acid is the only form of lipoic acid that is proven to significantly reduce inflammation, an underlying cause of aging. (5)
∑ R-Lipoic acid is the only form of lipoic acid that is proven to significantly increase your cellular and mitochondrial antioxidant activity for preventing mitochondrial decay. This effectively attenuates the reported increase in oxidative stress with aging. (8)
∑ R-Lipoic acid is the only form of lipoic acid that is shown to help improve memory, maintain healthy cognitive function, and protect the brain from neurodegeneration associated with aging. (8,9,22)
∑ R-Lipoic acid is the only form of lipoic acid that is shown to significantly increase insulin sensitivity, enhance glucose transport, increase metabolic rate and help prevent the gain in body fat from aging. (10,11)
∑ R-Lipoic acid is the only form of lipoic acid that is proven to protect body fats against oxidative damage, chelate harmful metals and promote healthy heart function. (12,13)
∑ R-Lipoic acid is the only form of Lipoic that is proven to significantly increase or maintain levels of other antioxidants including Coenzyme Q10, vitamin C, vitamin E and glutathione. (14,15)
The problems of S-Lipoic acid
∑ S-Lipoic acid produces different biological actions than R-Lipoic acid that may be undesirable. (16-18)
∑ S-Lipoic acid produces limited beneficial effects since it cannot bind with key enzymes. (19)
∑ S-Lipoic acid is less effective than R-Lipoic acid as an antioxidant. (20)
∑ At high concentrations, S-Lipoic acid inhibits mitochondria metabolism and the antioxidant activity of R-Lipoic acid (21)
∑ S-Lipoic acid is metabolized in the outer cell membrane. This may interfere with R-Lipoic acidís ability to penetrate the inner mitochondrial membrane and energy production. (22)
∑ R-Lipoic acid costs slightly more per unit than alpha-Lipoic acid. But it may be 10 times stronger than regular alpha-Lipoic acid at reducing inflammation, a primary cause of aging. And it is free of the problems from the S-form.
R-ALA sounds good, but the RALA Edge looks much more expensive
than standard ALA - is it worth it?
Since the ALA you get in stores is actually a 50/50 mixture of R-ALA and S-ALA, you would naturally assume that you would be getting twice the benefits from Pure R-ALA as you would from standard ALA. This is not correct. It has been shown in many studies that R-ALA is up to 12 times as effective as ALA. It has also been proven that the S-ALA portion can actually reduce the positive benefits of the R-ALA. This is why the pure naturally occurring R-ALA is considered by researchers and doctors to be many times as effective.
You will find companies selling large doses of the less expensive ALA. It is much more cost effective to take a smaller dose of pure R-ALA. You will not only spend less for your supplement but you will be gaining all the added benefits of the biologically active form of alpha lipoic acid without being forced to take any of the synthetic byproduct contained in the cheaper form.
Compare for yourself. You will find any of the trusted brand
standard ALA products priced less than our quality pure R-ALA Edge. Donít let
the lower price fool you, if it doesnít say 100% R-ALA, it isnít.
Supplement Facts on RALA EDGE:
150 Mg of 100% pure R+ Alpha Lipoic Acid per serving
100mcg of Biotin per serving
90 servings per bottle - 90 capsules
R-ALA Edge Retail Price - $49.95 for 90 capsules (90 servings)
PowerSupplements Special Low Price - $32.95 per bottle of R-ALA Edge
SORRY, THIS PRODUCT IS NO LONGER AVAILABLE
* Special - Free Shipping on any order over $100!
Want to learn more about R-ALA? Click
here to read our 20 page e-book on R-ALA.
1. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Biol Med 1995;19:227-250
2. Ou P, Tritschler HJ, Wolff SP. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem Pharmacol 1995; 50:123-126.
3. Hagen et al, "(R)-alpha-Lipoic acid-supplemented Old Rats Have Improved Mitochondrial Function, Decreased Oxidative Damage, and Increased Metabolic Rate," FASEB J 1999 13:411-418
4. Freisleben HJ, Neeb A, Lehr F, Ackermann H. Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice. Arzneimittelforschung 1997 Jun; 47(6): 776-80
5. Ulrich H, Weischer CH, et al. Pharmaceutical composition containing R-.alpha.-lipoic acid or S-.alpha.-lipoic acid as active ingredient. US Patent 5,728,735, 1998.
6. Hagen et al, op. cit.
7. Suh JH, et al, Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J 2001 Mar; 15(3): 700-6
8. Liu J, Head E, Gharib AM, et al, Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A 2002 Feb 19; 99(4): 2356-61
9. Hager K, Marahrens A, Kenklies M, et al, Alpha-lipoic acid as a new treatment option for Azheimer type dementia. Arch Gerontology Geriatric 2001 Jun; 32(3): 275-282
10. Jacob S, Rues P, Hermann R. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Rad Biol Med 1999 Aug;27(3-4):309-14
11. Moines H, Trios O, Park YC, Chow KJ, Packer L R-alpha-Lipoic Acid Action on Cell Redox Status, the Insulin Receptor, and Glucose Uptake in 3T3-L1 Adipocytes. . Arch Biochem Biophys 2002 Jan 15; 397(2): 384-91.
12. Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J 2001 Mar; 15(3): 700-6
13. Androne L, Gavan NA, Veresiu IA, Orasan R, In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo 2000 Mar-Apr; 14(2): 327-30
14. Suh JH, Shigeno ET, et al, Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J 2001 Mar; 15(3): 700-615. Lykkesfeldt J, et al, Ames BN. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation. FASEB J 1998 Sep; 12(12): 1183-9
16. Streeper RS, Henriksen EJ, et al, Tritschler HJ. Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 1997 Jul; 273(1 Pt 1): E185-91
17. Freisleben HJ, Neeb A, Lehr F, Ackermann H. Influence of selegiline and lipoic acid on the life expectancy of immunosuppressed mice Arzneimittelforschung 1997 Jun; 47(6): 776-80
18. Haramaki N, Han D, Handelman GJ, Tritschler HJ, Packer L. Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of alpha-lipoic acid Free Radic Biol Med 1997; 22(3): 535-42
19. Maitra I, Serbinova E, et al. Stereospecific effects of R-Lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. Biochem Biophys Res commun 1996; 221:422-429.
20. Streeper RS, Henriksen EJ, et al, Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol 1997 Jul; 273(1 Pt 1): E185-91
21. M.S. Patel, et al, Stereospecific effects of lipoic acids on mammalian pyruvate dehydrogenase complex
22. Packer, L; Tritschler, H; Wessel K, Neuroprotection by the metabolic Antioxidant alpha Lipoic Acid. 1997 Free Rad Biol Med 22, Nos 1/2, 359-378